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KMID : 0043320060290110952
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Archives of Pharmacal Research
2006 Volume.29 No. 11 p.952 ~ p.956
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Benzylamides from Salvadora persica
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Khalil Ashraf Taha
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Abstract
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A phytochemical investigation of stems from Salvadora persica resulted in the first isolation of four benzylamides from a natural source. The isolated compounds were identified as butanediamide, -bis(phenylmethyl)-2(S)-hydroxy-butanediamide (1), N-benzyl-2-phenylacetamide (2), N-benzylbenzamide (3) and benzylurea (4). The structure elucidation was accomplished using spectroscopic methods, especially 2D NMR and HREIMS. Compound 2 revealed a significant inhibitory effect on human collagen-induced platelet aggregation, and a moderate antibacterial activity against Escherichia coli.
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KEYWORD
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Salvadora persica, Benzylamides, Human antiplatelet aggregation effect, Antibacterial activity
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